Recommendations for the use of tryptase in the diagnosis of anaphylaxis and mastocytosis


Document published on La Rivista Italiana della Medicina di Laboratorio 2019 Settembre;15(3):211-24
DOI: 10.23736/S1825-859X.19.00022-7

In this review, we describe the various aspects related to the molecular characteristics of tryptase and its biological effects, the genetic basis of its production and the release kinetics. Recommendations are also given on the best procedure for a correct definition of the reference values in relation to the inter-individual variability and to the correct determination of tryptase in blood and other biological liquids, in the diagnosis of anaphylaxis (from drugs, food or insect bites), death from anaphylaxis (post mortem assessment) and cutaneous or systemic mastocytosis and mast cell activation syndrome.