280 - Local surveillance study of urinary tract infections in pediatric age: etiology and related susceptibility patterns

Autor(s): C. Mazzone, M. Laneve, F. Resta

Issue: RIMeL - IJLaM, Vol. 4, N. 4, 2008 (MAF Servizi srl ed.)

Page(s): 280-284

Urinary tract infections (UTI) are very common in the pediatric age. Infants and young children with UTI may have few specific symptoms. The epidemiology of UTI, during childhood, varies by age, sex, and other factors. The incidence of UTI is highest in the first year of life for all children but decreases substantially among boys after infancy. The objective of this study was to determine the etiology and antimicrobial susceptibility patterns of pathogens bacteria responsible of UTI, isolated in pediatric age. Methods. During the period July 2007 - July 2008, 606 urine samples were analysed. Total microbe load was acquired with a BIO-DETECTOR kit, while identification of germs was performed with the Apy system. Antibiotic susceptibility tests were assayed with the ATB UR strip. Results. The positive urinocoltures were 163 (27%) of a total of 606. Escherichia coli was the most common etiologic agent isolated (58.3%), followed by Klebsiella ssp. (12%), Pseudomonas aeruginosa (6%) and Proteus mirabilis (10%). Gram-positive bacteria accounted for only 7.4%, with prevalence of Enterococcus spp (4.3%) and Staphylococcus ssp (2.4%). The most effective antibiotics for Gram negative were: Imipenem, Amikacin, Ceftazidime and Cefotaxim, while for Gram positive were: Vancomycin and Oxacillin. Conclusions. Escherichia coli was the more frequently isolated microrganism among Gram negative bacteria, with a very high susceptibility to Amoxicillin. Currently, the empirical use of Cotrimoxazole and Amoxicillin is not recommended for Enterobacteriaceae. Current data on the multi-antibiotic resistance among isolated bacteria, should be seriously taken into consideration in order to change the current empiric treatment of UTI. Key-words: urinary tract infections, Escherichia coli, Staphylococcus aureus, pediatric age, antibiotic resistance.

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