106 - Urinary Albumin Excretion in chronic kidney disease: critical issues in measurement and reporting
Autor(s): M.S. Graziani
Issue: RIMeL - IJLaM, Vol. 5, N. 3-S1, 2009 (MAF Servizi srl ed.)
Page(s): 106
Urinary excretion of albumin is a cardinal sign of kidney disease and it is recognized as a risk factor for progression of kidney disease and cardiovascular disease. Because of its clinical importance there is an urgent need for an accurate measurement of the protein and for clearly reported results. The National Kidney Disease Education Program and the IFCC established a Working Group on “Microalbumin” with the aim to identify specific areas for improvement. At the moment there is a consensus opinion on the following issues: – the term “microalbumin” is to be discouraged, – first morning void is the preferable sample since provides a lower variability than other types of samples, – urinary albumin should not be measured in frozen sample (unless they have been stored at -70 °C), – an albumin/creatinine ratio (ACR) should be reported with all measurements, – albumin concentration in milligrams per litre should not be the only value reported….