115 - Pharmacogenetics: promise or reality?
Autor(s): RHN van Schaik
Issue: RIMeL - IJLaM, Vol. 5, N. 3-S1, 2009 (MAF Servizi srl ed.)
Page(s): 115
A common problem in medicine is that there are differences in how patients repond to drugs. Whereas most individuals will tolerate the standard dosages well, certain patients may either experience severe toxicity on the same dose, or may eventually show to be subtherapeutically treated. Since the 1960s, we are aware that individuals may differ in metabolizing capacity, due to genetic polymorphisms encosing drug metabolizing enzymes……