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028 - Detection of autoantibodies specific for transglutaminase-gliadin peptides complex: a new way to explore the celiac iceberg?

Autor(s): R. Tozzoli, G. Kodermaz, M. Tampoia, D. Visentini, E. Tonutti, N. Bizzaro

Issue: RIMeL - IJLaM, Vol. 6, N. 1, 2010 (MAF Servizi srl ed.)

Page(s): 28-35

Summary
Background. Identifying patients affected by celiac disease who have atypical clinical manifestations, or have silent or potential forms, represents one of the main objectives of the public health system, given that atleast 80% of these individuals remain undiagnosed. New discoveries in the pathogenesis of the disease point to an important role of the gliadin-transglutaminase complex which is able to evoke the production of specific antibodies against neopeptides of the complex as well as against gliadin peptides and tissue transglutaminase, which are the consolidated diagnostic markers of the disease. The aims of this study were: (a) to evaluate the analytical characteristics of a new immunoenzymatic method which utilizes the transglutaminase-gliadin peptides complex as solid phase; (b) to study the diagnostic sensitivity of the new method in healthy subjects and subjects affected by infectious diseases along with a group of celiac patients; and (c) to study the positivity frequency of autoantibodies in subjects affected by other systemic or organ-specific auto-immune diseases - which are considered groups at risk for celiac disease - and in subjects with various infectious pathologies. Materials and Methods. A total of 739 patients were studied, including 120 healthy subjects, 41 affected by celiac disease, 471 affected by autoimmune diseases other than celiac disease, and 106 subjects affected by infectious diseases. ....

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