Guidelines for the serological and histopathological diagnosis of celiac disease.
Autor(s): E. Tonutti, D. Visentini, N. Bizzaro, D. Villalta, M. Bagnasco, R. Tozzoli, M. Tampoia, D. Bassetti, M. Musso, M. Liguori, A. Antico, S. Platzgummer, F. Manoni, L. Camogliano, M. Pradella, V. Villanacci P. Ceppa, R. Fiocca
Issue: RIMeL - IJLaM, Vol. 1, N. 2, 2005 (MAF Servizi srl ed.)
Page(s): 110
The diagnosis of celiac disease is made on the basis of a
patient’s clinical and genetic history, the finding of specific
antibodies and auto-antibodies, and the evidence of
histological damage revealed by a duodenal biopsy. These
guidelines were written in order to provide education and
guidance for the appropriate use of serological and genetic
tests, and for the correct interpretation of the different
histological patterns. Differing diagnostic and explanatory
steps have been described so as to respond to various
needs (diagnoses, monitoring, groups at risk) and according
to the age of the patients. The recommendations have been
based on the authors’ personal experience, medical
literature, consensus reached on numerous points by the
study group, and the contributions from many who
participated in the discussion which followed the
publication of the preliminary version of the guidelines in
this same journal in 2002 and also on the website of the
SIMeL. Moreover, the current version is a model of
interdisciplinary work which has resulted from an effective
collaboration between clinical pathologists, immunologists
and surgical-pathologists.