Autor(s): N. Bizzaro
Based on the natural history of both rheumatic and organ-specific autoimmune diseases, many antibodies can be observed years before the appearance of the first symptoms and clinical diagnosis. The new multiplex and microarray diagnostic techniques, capable of the simultaneous detection of several different antibodies, will enable in the near future to obtain very wide antibody profiles and conduct large population screenings. At the same time, however, it would create problems related to the interpretation of positive results in asymptomatic patients, and also of an ethical nature. Therefore, the diagnostic accuracy of the assay methods is crucial: in order to minimize false positive results, it will be of paramount importance to use highly specific diagnostic methods. This study evaluates those various antibodies and their associated pathologies that have been proven to be involved in the forecasting of an autoimmune disease.