088 - Determination of Ischemia Modified Albumin in emergency medicine
Autor(s): G. Lippi, M. Montagnana, G.C. Guidi
Issue: RIMeL - IJLaM, Vol. 3, N. 2, 2007 (MAF Servizi srl ed.)
Page(s): 88-93
Enhanced generation of free radicals and other reactive species following reperfusion of ischemic tissues is associated with alteration of the protein structure, metabolism and function. In the human albumin moiety, free radicals-induced oxidative modifications at the N-terminal region impair the binding capacity to transition metals, such as nickel and cobalt. This peculiar form of modified albumin is hence designated as ischemia modified albumin (IMA), which can be assayed in serum or plasma by a simple and rapid colorimetric assay. Preliminary clinical evidences indicate that IMA measurement may provide useful information on the risk of cardiovascular events, enabling recognition of myocardial ischemia before the onset of irreversible cardiac injury and necrosis. In association with traditional biomarkers of myocardial damage, a nondiagnostic IMA value would efficiently rule out cardiac ischemia and consideration could be made to either formulate an alternative diagnosis or discharge the patient. A positive IMA value could also help to identify higher risk individuals, suffering from local or systemic hypoxic conditions, who may benefit from early triage and intervention.