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134 - Laboratory diagnosis of chronic inflammatory bowel disease

Autor(s): E. Tonutti

Issue: RIMeL - IJLaM, Vol. 4, N. 2, 2008 (MAF Servizi srl ed.)

Page(s): 134-137

Laboratory markers of inflammation are useful for the diagnosis and the monitoring of inflammatory bowel disease (IBD). Of all the laboratory markers, C reactive protein (CRP) has been shown to correlate well with disease activity both in Crohn’s disease (CD) as well as in Ulcerative Colitis (UC). Faecal markers are more specific in detecting gut inflammation in patients with IBD. Promising results have been reported with the use of faecal calprotectin in the diagnosis and in the follow up of CD and UC patients. A variety of serological test are emerging that are relevant to the diagnosis of CD and UC; these tests include: anti-neutrophil cytoplasmic antibody with perinuclear staining (P-ANCA), anti-Saccharomyces cerevisiae antibody (ASCA), outer membrane porin C antibody (anti-OmpC), anti- I2 antibody (novel homologue of the bacterial transcription- factor families) and a new group of antibodies against glycans as anti-laminaribioside (ALCA) antichitobioside (ACCA) and anti-mannobioside (AMCA). This article rewies the use of these markers in patients with IBD

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