068 - Diagnosis of celiac disease: not only anti-transglutaminase
Autor(s): E. Tonutti
Issue: RIMeL - IJLaM, Vol. 4, N. 3-S1, 2008 (MAF Servizi srl ed.)
Page(s): 68-71
transglutaminase Celiac disease is a syndrome characterized by damage of the small intestinal mucosa caused by the gliadin fraction of wheat, barley and rye in genetically susceptible subjects. Serologic tests developed in the last decade provide a non invasive tool to screen individuals at risk for the disease. The diagnostic role of assays to identify anti-transglutaminase, anti-endomysium and anti-gliadin antibodies was discussed. Particular attention was pointed to the IgA deficiency and to the utilization of tests for the determination of HLA DQ2/DQ8 haplotypes. Technical and diagnostic performances of anti-actin, anti-transglutaminase and anti-endomysium antibody assay in culture medium from duodenal mucosa were analyzed.