077 - Haemostasis: the researches of three Italian physicians in the XIXth century

Autor(s): G. Dall'Olio

Issue: RIMeL - IJLaM, Vol. 5, N. 2, 2009 (MAF Servizi srl ed.)

Page(s): 77-82

In these paper is reported the contribution to the know- ledge on haemostasis of three Italian physicians of the XIXth century. In order to reduce bleeding during surgical procedures, especially the massive haemorrhage in case of limbs amputation, in 1853 the surgeon Olinto Grandesso-Silvestri suggested the ligature of limbs with elastic rubber cords to block blood circulation. He was regarded as the inventor of the elastic rubber ligature in surgery. Paolo Mantegazza in 1869 proposed a blood coagulation theory closely related to white blood cells. In peculiar conditions, these cells produce a substance, the fibrin, forming the blood clot. In 1882, Giulio Bizzozero discovered the platelets and carefully described their important function in throm- bosis and blood coagulation.
Key-words: Historical article, Biography, Blood platelets/ physiology, Hematology/history, Haemastasis, Fibrinogen, Bleeding, Elastic band.

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