SIPMeL - Società Italiana di Patologia clinica e Medicina di Laboratorio

Webinar ISLH di dicembre 2025

04/12/2025

Si conclude il 2025 con il seminario di dicembre della International Society for Laboratory Hematology (ISLH).

Giovedì 18 dicembre alle 17 italiane (11:00 AM ET), Alexa J. Siddon, MD Yale University School of Medicine presenterà un seminario dal titolo: "ICC and WHO Classifications
of Myeloid Malignancies".

Maria Roussakis University of Southern Queensland, sarà la moderatrice del webinar.

La partecipazione è gratuita.

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Overview:

The following presentation reviews the major updates in the WHO 5th Edition and International Consensus Classification (ICC) systems for myeloid malignancies, highlighting the increasing integration of molecular genetics into disease definition, prognosis, and management. Key topics include the recognition of clonal hematopoiesis, updated diagnostic thresholds for MDS and AML, and the molecular characterization of entities such as SF3B1-mutated MDS, TP53-mutated myeloid neoplasms, and genetically defined AML subtypes. The talk emphasizes how advances in sequencing technologies and expanding knowledge of driver mutations have reshaped classification systems and clinical practice.

Learning Objectives:

  • Understand the major updates in the WHO-5th edition and ICC classifications of myeloid malignancies, including how molecular features now define or refine categories.
  • Recognize the diagnostic and prognostic significance of key driver mutations.
  • Apply updated classification principles to clinical hematopathology practice, including evaluating blast thresholds, integrating cytogenetic and molecular data, and selecting appropriate testing methods.

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