206 - BNP e NT-proBNP nella diagnosi di insufficienza cardiaca e nella prognosi di pazienti con sindrome coronarica acuta
Rivista: RIMeL - IJLaM, Vol. 1, N. 3, 2005 (MAF Servizi srl ed.)
P. Cappelletti, D. Rubin, P. Bulian, M. Cassin, F. Macor, GL. Nicolosi
Diagnostic accuracy and prognostic value of Brain
Natriuretic Peptide (BNP) and N-Terminal pro Brain
Natriuretic Peptide (NT-proBNP) in patients with
Acute Coronary Syndrome (ACS)
Background. There are controversial evidences about the
diagnostic accuracy and prognostic value of BNP and NTproBNP
in patients with ACS. The aim of the study was
to compare diagnostic and prognostic performances of
BNP and NT-proBNP in one group of consecutive
patients with ACS.
Methods.189 EDTA plasma and serum samples from
patients admitted at CCU for ACS with and without STelevation
(ST-ACS n. 63 and NST-ACS n. 126) have been
assayed for BNP and NT-proBNP by chemiluminescent
methods on Bayer ADVIA CENTAUR® and Roche
ELECSYS® respectively. ROC analysis was used for
studying diagnostic accuracy in identifying heart failure -defined as left ventricular ejection fraction (LVEF) < 40%
- and in identifying adverse prognosis at 30 days of followup
- end points: death, hearth failure, new infarct and
unstable angina (readmission). The Mc Nemar test was
used for comparing biochemical classification at optimal
cut-off identified by ROC analysis.
Results. For identification of patients with LVEF