206 - BNP e NT-proBNP nella diagnosi di insufficienza cardiaca e nella prognosi di pazienti con sindrome coronarica acuta

P. Cappelletti, D. Rubin, P. Bulian, M. Cassin, F. Macor, GL. Nicolosi Diagnostic accuracy and prognostic value of Brain Natriuretic Peptide (BNP) and N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) in patients with Acute Coronary Syndrome (ACS) Background. There are controversial evidences about the diagnostic accuracy and prognostic value of BNP and NTproBNP in patients with ACS. The aim of the study was to compare diagnostic and prognostic performances of BNP and NT-proBNP in one group of consecutive patients with ACS. Methods.189 EDTA plasma and serum samples from patients admitted at CCU for ACS with and without STelevation (ST-ACS n. 63 and NST-ACS n. 126) have been assayed for BNP and NT-proBNP by chemiluminescent methods on Bayer ADVIA CENTAUR® and Roche ELECSYS® respectively. ROC analysis was used for studying diagnostic accuracy in identifying heart failure -defined as left ventricular ejection fraction (LVEF) < 40% - and in identifying adverse prognosis at 30 days of followup - end points: death, hearth failure, new infarct and unstable angina (readmission). The Mc Nemar test was used for comparing biochemical classification at optimal cut-off identified by ROC analysis. Results. For identification of patients with LVEF